Statin Therapy and Risk of Developing Type 2 Diabetes

Kim, Sung Rae

doi:2010.11.4.254

J Korean Diabetes > Volume 11(4); 2010 > Article

Opinion

The Journal of Korean Diabetes 2010;11(4):254-258.
DOI: https://doi.org/10.4093/kcd.2010.11.4.254

스타틴과 당뇨병의 발생

김성래

Statin Therapy and Risk of Developing Type 2 Diabetes

Sung Rae Kim

Abstract

Although the results of previous randomised statin trials indicate that interventions that lower LDL cholesterol concentrations can significantly reduce the incidence of coronary heart disease (CHD) and other major vascular events, the relationship between LDL and the development of diabetes remains controversial. The West of Scotland Coronary Prevention Study (WOSCOPS) evaluated this relationship and reported a small protective effect associated with lowering LDL concentrations, but did not use standardised criteria for diabetes diagnoses. In the JUPITER trial, 17,802 adults without clinical or biochemical diagnoses of diabetes based on fasting glucose concentrations were assigned either rosuvastatin or placebo for a median of 1.9 years. Significantly more individuals in the statin group than in the placebo group developed diabetes. Recently, Rajpathak (YEAR) and Naveed (YEAR) meta-analysed statin and develop diabetes. Statin therapy is associated with a slightly increased risk of diabetes, but the risk is low both in absolute terms and when compared to the reduction in coronary events. Current clinical practices for patients with moderate or high cardiovascular risk or existing cardiovascular disease should not change. (Korean Clinical Diabetes J 11:254-258, 2010)

Key Words: LDL cholesterol, Statin, Type 2 diabetes