The Journal of Korean Diabetes 2008;9(3):228-234.
혼합결합조직병의 중첩증후군과 하시모토 갑상선염을 동반한 B형 인슐린저항성 1예
이상렬, 구보경, 박은경, 송은주, 백대현, 이성혁, 김효정, 한경아, 민경완
A Case of Type B Insulin Resistance Syndrome Accompanied with Mixed Connective Tissue Disease and Hashimoto`s Thyroiditis
Sang Ryul Lee, Bo Kyung Koo, Eun Kyoung Park, Eun Ju Song, Dae Hyun Baek, Sung Hyuck Lee, Hyo Jeong Kim, Kyung Ah Han, Kyung Wan Min
The type B insulin resistance syndrome is a manifestation of autoantibodies to the insulin receptor. The disease causes the hyperinsulinemia and a spectrum of abnormalities in glucose homeostasis, ranging from extreme insulin resistance to fasting hypoglycemia. It is known to be related with autoimmune diseases. We report a case of the type B insulin resistance syndrome which was presented as severe hyperglycemia resistant to large amount of insulin. This case showed manifestations of other autoimmune diseases such as Hashimoto`s thyroiditis and overlap syndrome of mixed connective tissue disease as well as hyperinsulinemia and acanthosis nigricans related with extreme insulin resistance. Short period of steroid therapy (prednisolone 30 mg/day for 8 days) made a clinical improvement in this case.
Key Words: Hashimoto`s thyroiditis, Hyperinsulinemia, Insulin resistance, Overlap syndrome of mixed connective tissue disease, Receptor antibody
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