The Journal of Korean Diabetes 2008;9(3):228-234.
혼합결합조직병의 중첩증후군과 하시모토 갑상선염을 동반한 B형 인슐린저항성 1예
이상렬, 구보경, 박은경, 송은주, 백대현, 이성혁, 김효정, 한경아, 민경완
A Case of Type B Insulin Resistance Syndrome Accompanied with Mixed Connective Tissue Disease and Hashimoto`s Thyroiditis
Sang Ryul Lee, Bo Kyung Koo, Eun Kyoung Park, Eun Ju Song, Dae Hyun Baek, Sung Hyuck Lee, Hyo Jeong Kim, Kyung Ah Han, Kyung Wan Min
Abstract
The type B insulin resistance syndrome is a manifestation of autoantibodies to the insulin receptor. The disease causes the hyperinsulinemia and a spectrum of abnormalities in glucose homeostasis, ranging from extreme insulin resistance to fasting hypoglycemia. It is known to be related with autoimmune diseases. We report a case of the type B insulin resistance syndrome which was presented as severe hyperglycemia resistant to large amount of insulin. This case showed manifestations of other autoimmune diseases such as Hashimoto`s thyroiditis and overlap syndrome of mixed connective tissue disease as well as hyperinsulinemia and acanthosis nigricans related with extreme insulin resistance. Short period of steroid therapy (prednisolone 30 mg/day for 8 days) made a clinical improvement in this case.
Key Words: Hashimoto`s thyroiditis, Hyperinsulinemia, Insulin resistance, Overlap syndrome of mixed connective tissue disease, Receptor antibody
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