J Korean Diabetes > Volume 19(1); 2018 > Article
The Journal of Korean Diabetes 2018;19(1):23-30.
DOI: https://doi.org/10.4093/jkd.2018.19.1.23    Published online April 13, 2018.
제2형 당뇨병의 경구혈당강하제 병합요법
Combination Therapy of Oral Hypoglycemic Agents in Patients with Type 2 Diabetes Mellitus.
Min Kyong Moon
Department of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea. mkmoon@snu.ac.kr
The Korean Diabetes Association (KDA) recently updated the Clinical Practice Guidelines on antihyperglycemic agent therapy for adult patients with type 2 diabetes mellitus (T2DM). In combination therapy of oral hypoglycemic agents (OHAs), general recommendations were not changed compared to those of 2015 KDA guidelines. The committee of Clinical Practice Guideline of KDA has extensively reviewed and discussed the results of meta-analyses and systematic reviews of the effectiveness and safety of OHAs and many clinical trials on Korean patients with T2DM for the update of guidelines. All OHAs were effective when added to metformin or metformin and sulfonylurea, although the effects of each agent on body weight and hypoglycemia were different. Therefore, selection of a second agent as a metformin add-on therapy or a third agent as a metformin and sulfonylurea add-on therapy should be based on the patient's clinical characteristics and the efficacy, side effects, cardiovascular benefit, risk of hypoglycemia, effect on body weight, patient preference, and combined comorbidity.
Key Words: Diabetes mellitus, type 2, Hypoglycemic agents, combination, Practice guideline, Treatment outcome

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