The Effect of Nateglinide on Postprandial Hyperglycemia and Oxidative Stress in Patients with Type 2 Diabetes Mellitus

Cho, Min Ho; Jung, Han Young; Yoon, Ji Eun; Nam, Ji Sun; Kim, Hai Jin; Park, Jong Suk; Kang, Eun Seok; Ahn, Chul Woo; Cha, Bong Soo; Lim, Sung Kil; Kim, Kyung Rae; Lee, Hyun Chul

Clinical Diabetes 2007;8(Suppl DB Error: syntax error):48-56.

원저 및 증례 : 제2형 당뇨병환자에서 나테글리니드가 식후 고혈당 및 산화성 스트레스에 미치는 영향

조민호, 정한영, 윤지은, 남지선, 김혜진, 박종숙, 강은석, 안철우, 차봉수, 임승길, 김경래, 이현철

The Effect of Nateglinide on Postprandial Hyperglycemia and Oxidative Stress in Patients with Type 2 Diabetes Mellitus

Min Ho Cho, Han Young Jung, Ji Eun Yoon, Ji Sun Nam, Hai Jin Kim, Jong Suk Park, Eun Seok Kang, Chul Woo Ahn, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee

Abstract

Background
Postprandial glucose level in type 2 diabetes is very important because it has strong correlation with macrovascular complications. Oxidative stress is factor of development and progression of macrovascular complications. The aim of this study is to provide a pharmacologic therapy meeting the means for reducing the risk for macrovascular complications. Materials and Methods: Total 60 type 2 diabetic patients were divided nateglinide group and control group. After 12 weeks, changes of postprandial glucose and oxidative stress were evaluated. Results: Compared with controls, the nateglinide administration group had significant postprandial glucose lowering, and reduced MDA (malondialdehyde) absorption levels. Conclusion: Nateglinide administration for type 2 diabetes, give a possibility of prevention macrovascular complication by lowering postprandial glucose and oxidative stress.

Key Words: Nateglinide, Macrovascular complication, Oxidative stress