Clinical Diabetes 2006;7(4):349-357.
당뇨병환자에서 Intimascope(R)을 이용한 경동맥 내중막 두께 측정의 정확성과 효율성
조민호, 유재명, 문홍주, 강준구, 이병완, 이성진, 홍은경, 김현규, 김두만, 임성희, 최문기, 유형준
The Accuracy and Efficiency of Intimascope(R) for Measuring Carotid Artery Intima-media Thickness in Diabetes
Min Ho Cho, Jae Myung Yu, Hong Ju Moon, Jun Goo Kang, Byung Wan Lee, Sung Jin Lee, Eun Gyoung Hong, Hyun Kyu Kim, Doo Man Kim, Sung Hee Ihm, Mun Ki Choi, Hyung-Joon Yoo
Atherosclerosis is the major cause of diabetic macrovascular complication. In many studies, the measurement of carotid artery intima-media thickness (cIMT) is reported as a good-correlation with atherosclerosis risk factors and as a tool to detect atherosclerosis. But the method of measuring cIMT has not been standardized, and in spite of same method, observational error existed frequently because of different inspectors. So computer softwares have been developed to correct these subjective errors, and to standardize method. The aim of this study is to evaluation the accuracy and efficacy of Intimascope(R), a software of measuring cIMT, by comparing with conventional 3-point evaluation method. Methods: Conventional 3-point cIMT measurement was performed to diabetes and the ulrasonographic data was analyzed by Intimascope(R). To evaluation of accuracy, we compared the average and maximum values between two methods. To evaluate efficacy, we investigated cases needs to modification due to misread ulrasonographic data by Intimascope(R) analysis. Results: Total 211 diabetic patients were enrolled. 1) Between two methods, there was significant difference in the average cIMT (0.820 ± 0.167 vs 0.765 ± 0.161 mm, P < 0.001) and the maximal cIMT (0.897 ± 0.191 vs 0.911 ± 0.201 mm, P = 0.02). But 3-point average evaluation by Intimascope(R) analysis, not continuous analysis, was no significant difference in the conventional method (0.820 ± 0.167 vs 0.812 ± 0.159 mm, P = 0.24). 2) There were 51 cases need to modification. In chi-square analysis, previous macrovascular history was significant factor to modify ultrasonographic data (P < 0.001). Conclusion: The cIMT measurement by Intimascope(R) may be equivalent method compared with conventional 3-point evaluation. But frequent modification was needed due to misread intima-media line and misreading frequency was high in patients with previous macrovascular complication history. In summary, Intimascope(R) is accurate and efficient method for diabetic patients with no previous macrovascular complication history. To complicated diabetic patients, modification could be needed frequently and observational error should be considered.
Key Words: Carotid intima-media thickness, Diabetes, Intimascope(R)

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