A Case of Diabetic Ketoacidosis in Association with Acanthosis Nigricans

You, Sung Soo; Kwon, Hyun Hee; Park, Kyoung Chan; Yoon, Hyun Dae; Lee, Ji Hyun; Son, Ho Sang

Case Report

Diabetes Monit 2002;3(3):280-286.

흑색극세포증에 동반된 당뇨병성 케톤산혈증 1예

유성수, 권현희, 박경찬, 윤현대, 이지현, 손호상

A Case of Diabetic Ketoacidosis in Association with Acanthosis Nigricans

Sung Soo You, Hyun Hee Kwon, Kyoung Chan Park, Hyun Dae Yoon, Ji Hyun Lee, Ho Sang Son

Abstract

Acanthosis nigricans is a skin lesion characterized by localized areas of brown hyperpigmented and velvety hyperplastic skin. Typically, it is found at body folds such as the neck and axilla. This condition is frequently accompanied by insulin resistance, hyperinsulinemia and obesity or it may be a signal of underlying malignant disorder, such as gastric cancer. Although diabetic ketoacidosis may develop in patients with type 2 diabetes when they experience severe metabolic stress, it usually occurs only in individuals whose circulating insulin is virtually absent. Because acanthosis nigricans is seen in insulin-resistant states or hyperinsulinemic states, patients with acanthosis nigricans are not likely to develop diabetic ketoacidosis. Because of the unexpected occurrence of diabetic ketoacidosis in association with acanthosis nigricans, we report this case.

Key Words: Acanthosis nigricans, Diabetic ketoacidosis