Medical Therapy in Pregnant Women with Diabetes.

Lee,  Seok Hong; Ahn,  Jihyun; Kim,  Jaetaek

doi:2011.12.4.201

J Korean Diabetes > Volume 12(4); 2011 > Article

Focused Issue

The Journal of Korean Diabetes 2011;12(4):201-204.
DOI: https://doi.org/10.4093/kcd.2011.12.4.201 Published online December 1, 2011.

임산부에서 당뇨병의 약물치료

이석홍, 안지현, 김재택

Medical Therapy in Pregnant Women with Diabetes.

Seok Hong Lee, Jihyun Ahn, Jaetaek Kim

Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. jtkim@cau.ac.kr

Abstract

Pregnant women with diabetes are at greater risk for adverse outcomes, such as miscarriage, macrosomia, and preterm birth. Advances in the care of diabetes have reduced maternal and perinatal mortality rates to the levels expected in nondiabetic pregnancies. Lifestyle modification such as medical nutritional therapy and exercise is a first step in therapy for gestational diabetes. Rapid-acting insulin analogs (lispro, aspart) are comparable in safety and superior in glucose control to regular human insulin. Because the safety of long-acting insulin analogs (glargine, detemir) in pregnancy has not firmly established, the use of human insulin is preferred over basal insulin. Among the oral hypoglycemic agents, metformin and glyburide might be considered as alternative therapies.

Key Words: Pregnancy, Gestational diabetes, Insulin, Hypoglycemic agents, Oral administration