당뇨병이 치매에 미치는 영향 및 예방법 |
김수경 |
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Effect of Diabetes on Dementia and Its Preventive Strategies. |
Soo Kyung Kim |
Division of Endocrinology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Sungnam, Korea. imdrksk@chollian.net |
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Abstract |
There is considerable evidence that type 2 diabetes and its related conditions increase the risk of dementia, although the associations are stronger for vascular dementia than Alzheimer's disease. In addition to cerebrovascular disease, type 2 diabetes mellitus and dementia share several other pathophysiologic features, including hyperinsulinemia, advanced glycation end-product, inflammation, and amyloid deposition. From a clinical perspective, evidence of a link between type 2 diabetes and dementia would suggest that currently available modalities to prevent or treat type 2 diabetes mellitus might be beneficial in preventing dementia, especially Alzheimer's disease. This review summarizes the existing evidence of a link between type 2 diabetes and dementia and the clinical trials that have investigated the effects of anti-diabetic modalities on cognitive outcomes in patients with type 2 diabetes mellitus or its precursor conditions. |
Key Words:
Alzheimer disease, Type 2 diabetes mellitus, Vascular dementia |
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