J Korean Diabetes > Volume 14(3); 2013 > Article
The Journal of Korean Diabetes 2013;14(3):133-137.
DOI: https://doi.org/10.4093/jkd.2013.14.3.133    Published online September 30, 2013.
아시아인과 비아시아인에서 DPP-4 억제제 효과의 비교
김영기, 조영민
Comparison of the Efficacy of Dipeptidylpeptidase-4 Inhibitors Between Asian and Non-Asian Populations.
Yeong Gi Kim, Young Min Cho
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. ymchomd@snu.ac.kr
Abstract
Type 2 diabetes is different between Asian and non-Asian populations. Compared with their Caucasian counterparts, Asian patients with type 2 diabetes have the characteristics of lower body mass index, lower insulin secretory response, and a lower degree of insulin resistance. Furthermore, a recent study revealed that the incretin effect is not decreased in Korean patients with type 2 diabetes compared with normal glucose tolerance. The HbA1c lowering efficacy of dipeptidylpeptidase-4 inhibitors, which enhances active incretin hormones, is greater in Asian people than in non-Asian people, which could be ascribed to their lower body mass indexes. Therefore, doctors should take these differing characteristics of type 2 diabetes in Asian patients into account for customized anti-diabetes therapy.
Key Words: Dipeptidylpeptidase-4 inhibitor, Type 2 diabetes mellitus, Asian population, Body mass index
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