J Korean Diabetes > Volume 15(1); 2014 > Article
The Journal of Korean Diabetes 2014;15(1):7-11.
DOI: https://doi.org/10.4093/jkd.2014.15.1.7    Published online March 31, 2014.
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Methods for the Assessment of Insulin Resistance.
Hyejin Lee
Division of Endocrinology and Metabolism, Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. hyejinlee@ewha.ac.kr
Abstract
Insulin resistance is one of the major aggravating factors for metabolic disease. There are many methods available for estimation of insulin resistance which range from complex techniques down to simple indices. For all methods of assessing insulin resistance, it is essential that their validity and reliability be established before using them in clinical investigations. The reference techniques of hyperinsulinemic euglycemic clamp and its alternative,the frequently sampled intravenous glucose tolerance test, are the most reliable methods available for estimating insulin resistance. However, there are many simple methods from which indices can be derived that have been assessed and validated, which include homeostasis model assessment (HOMA) and the quantitative insulin sensitivity check index (QUICKI). Given the increasing number of simple indices of insulin resistance, it may be difficult for clinicians and researchers to select the most appropriate index for their studies. In planning studies on insulin resistance and selecting a suitable index, a number of important factors need to be considered by investigators, the principle one being the nature of the study to be undertaken.
Key Words: Insulin resistance, Glucose clamp technique
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