Two Cases of Diabetic Ketoacidosis Associated with Paliperidone Treatment in Schizophrenia.

Kim,  Hyun Ho; Yang,  Hae Kyung; Ham,  Hyoju; Jeon,  Ho Wook; Lee,  Joon Yub; Hwang,  Sea Won; Jang,  Bo Hyun; Min,  Gi June; Lee,  Jeong Min; Lee,  Seung Hwan

doi:2014.15.3.178

J Korean Diabetes > Volume 15(3); 2014 > Article

Original Articles & Case Reports

The Journal of Korean Diabetes 2014;15(3):178-184.
DOI: https://doi.org/10.4093/jkd.2014.15.3.178 Published online September 30, 2014.

Paliperidone을 복용한 정신분열병 환자에서 발생한 당뇨병성 케톤산증 2예

김현호, 양혜경, 함효주, 전호욱, 황세원, 장보현, 민기준, 이정민, 이승환

Two Cases of Diabetic Ketoacidosis Associated with Paliperidone Treatment in Schizophrenia.

Hyun Ho Kim, Hae Kyung Yang, Hyoju Ham, Ho Wook Jeon, Joon Yub Lee, Sea Won Hwang, Bo Hyun Jang, Gi June Min, Jeong Min Lee, Seung Hwan Lee

¹Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. hwanx2@catholic.ac.kr
²Division of Endocrinology and Metabolism, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

Atypical antipsychotics, which have better efficacy and fewer side effects compared to first-generation antipsychotics, are being used increasingly for the treatment of schizophrenia. However, adverse events such as weight gain, diabetes mellitus and abnormal lipid profile have been reported in patients treated with these agents. Diabetic ketoacidosis (DKA) is a rare side effect of atypical antipsychotics, but deserves attention due to its severity. Although various atypical antipsychotics have been reported as causing DKA, there have been no reports showing an association with DKA and paliperidone, which is a recently developed antipsychotic agent. Here, we report two cases of DKA in patients with paliperidone therapy. Both cases had no history of diabetes before use of paliperidone, and DKA was manifested within 2 years of starting paliperidone therapy. Like other atypical antipsychotics, use of paliperidone warrants monitoring for metabolic derangements including DKA.

Key Words: Diabetic ketoacidosis, Paliperidone, Schizophrenia