J Korean Diabetes > Volume 15(4); 2014 > Article
The Journal of Korean Diabetes 2014;15(4):216-220.
DOI: https://doi.org/10.4093/jkd.2014.15.4.216    Published online December 29, 2014.
일주기 리듬 장애와 대사증후군
김다함, 조영석
Circadian Rhythm Disruption and Metabolic Syndrome.
Daham Kim, Young Suk Jo
1Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul, Korea.
2Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. joys@yuhs.ac
Metabolic syndrome is a complex disorder and an emerging clinical challenge. It is induced by the interplay of genetic and environmental factors. Recently, evidence has emerged to suggest that circadian rhythm disruption is a new risk factor to explain the increased incidence of metabolic syndrome. This review summarizes circadian rhythm biology and the evidence linking circadian rhythm disruptions to metabolic syndrome, as related to lipid metabolism, glucose homeostasis, and cardiovascular function. Further understanding of circadian rhythm will aid the development of novel therapeutic strategies for metabolic syndrome.
Key Words: Circadian rhythm, Metabolic syndrome, Obesity, Diabetes mellitus, Cardiovascular disease
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