J Korean Diabetes > Volume 16(1); 2015 > Article
The Journal of Korean Diabetes 2015;16(1):78-82.
DOI: https://doi.org/10.4093/jkd.2015.16.1.78    Published online March 26, 2015.
한국인 제2형 당뇨병 환자에서 발병한 당뇨병 신경병증 악액질: 국내 첫 증례 보고
민기준, 조익현, 최영, 최준영, 박진희, 정성민, 강보라미, 이승환, 윤건호, 양혜경
Diabetic Neuropathic Cachexia in a 50-Year-Old Woman with Type 2 Diabetes: First Case Report in Korea.
Gi June Min, Ik Hyun Jo, Young Choi, Joon Young Choi, Jin Hee Park, Sung Min Jung, Borami Kang, Seung Hwan Lee, Kun Ho Yoon, Hae Kyung Yang
1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. cmcyang@gmail.com
2Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Diabetic neuropathic cachexia (DNC) is one of the rarest presentations of diabetic neuropathy associated with profound weight loss. A 50-year-old Korean woman with poorly controlled type 2 diabetes complained of intractable pain in the trunk and lower extremities, and total body weight loss of 17% over a 6 month period. The patient's symptoms persisted after glucose control and various medications for neuropathic pain. A diagnosis of DNC was made based on the rapid onset of severe pain, polyneuropathy, and marked weight loss without evidence of end organ disease other than mild retinopathy, and the exclusion of other possible causes. Spontaneous improvement of the patient's neuropathic pain and gradual weight gain occurred after 6 months of supportive care. Since the original report of DNC, 31 cases have been published in the English-language literature; however, ours is the first reported case in Korea. Clinicians must be aware of this debilitating complication of diabetes because of its severity and rapid progression.
Key Words: Cachexia, Diabetic neuropathies, Korea

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