J Korean Diabetes > Volume 16(4); 2015 > Article
The Journal of Korean Diabetes 2015;16(4):315-322.
DOI: https://doi.org/10.4093/jkd.2015.16.4.315    Published online December 24, 2015.
인터페론-알파 치료로 호전된 만성 C형 간염 환자의 당뇨병
박희수, 김윤정, 문수윤, 우지영, 최재균, 김경업, 박주리, 손호영, 김두만
Resolution of Type 2 Diabetes Mellitus Following Interferon-alpha Therapy for Chronic Hepatitis C.
Hee Su Park, Yoon Jung Kim, Soo Yoon Moon, Ji Young Woo, Jae Kyun Choi, Kyung Up Kim, Ju Ri Park, Ho Young Son, Doo Man Kim
Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. dm@hallym.or.kr
Hepatitis C virus (HCV) mainly affects the liver, but several tissues outside the liver have also been reported to be involved. It has been hypothesized that diabetes could be one of these extrahepatic conditions attributable to HCV infection. The specific mechanisms by which HCV leads to type 2 diabetes are not fully understood, but it seems that an increase in insulin resistance associated with both steatosis and overproduction of proinflammatory cytokines could play a crucial role. We report a patient whose type 2 diabetes that was resolved following interferon-alpha (IFN-alpha) therapy for HCV. A 57-year-old man presented with fatigue, polyuria, and polydipsia. He was newly diagnosed as type 2 diabetes and chronic hepatitis C. He was started on subcutaneous insulin and IFN-alpha. After 24 weeks of treatment with IFN-alpha, the results of HCV polymerase chain reaction were negative, and his diabetes had resolved. Our case shows a resolution of diabetes after IFN-alpha therapy for chronic hepatitis C. Although it is unclear whether the resolution of diabetes in this case occurred as an effect of IFN-alpha or as a result of becoming HCV RNA-negative, our finding suggest roles of IFN-alpha and HCV infection in the pathogenesis of diabetes.
Key Words: Hepatitis C virus, Interferon-alpha, Type 2 diabetes mellitus

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