Gut Microbiota and Diabetes

Lyu, Young Sang; Kim, Jin Hwa; Kim, Sang Yong

doi:2024.25.3.117

J Korean Diabetes > Volume 25(3); 2024 > Article

Opinion

The Journal of Korean Diabetes 2024;25(3):117-123.
DOI: https://doi.org/10.4093/jkd.2024.25.3.117 Published online September 30, 2024.

당뇨병과 장내 미생물

류영상, 김진화, 김상용

조선대학교 의과대학 조선대학교병원 내분비대사내과

Gut Microbiota and Diabetes

Young Sang Lyu, Jin Hwa Kim, Sang Yong Kim

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chosun University Hospital, Chosun University School of Medicine, Gwangju, Korea

Correspondence: Sang Yong Kim,
Email: diabetes@chosun.ac.kr

Received: 31 July 2024 • Accepted: 5 August 2024

Abstract

Type 2 diabetes is rapidly increasing worldwide and is closely linked to factors such as obesity, genetic predispositions, and lifestyle choices. Recent studies emphasize the significant role of gut microbiota in the development and progression of diabetes and other related metabolic diseases. It is also known that the effects and side effects of antidiabetic drugs can be influenced by gut microbiota. Recently, various therapeutic strategies have aimed at modulating gut microbiota for health improvement. Key approaches include the use of probiotics to enhance the balance of beneficial bacteria and prebiotics, which are dietary fibers that promote the growth of these beneficial bacteria. Additionally, the potential of fecal microbiota transplantation in restoring a balanced microbiota composition in individuals with metabolic diseases are explored. This review highlights the promising potential of these interventions in the prevention and management of type 2 diabetes, suggesting that gut microbiota could be a novel and effective approach in diabetes treatment and control.

Key Words: Diabetes mellitus, Fecal microbiota transplantation, Gastrointestinal microbiome, Probiotics