Postprandial Hyperglycemia and Cardiovascular Disease.

Yoon,  Ji Sung

doi:2012.13.1.18

J Korean Diabetes > Volume 13(1); 2012 > Article

Focused Issue

The Journal of Korean Diabetes 2012;13(1):18-22.
DOI: https://doi.org/10.4093/jkd.2012.13.1.18 Published online March 31, 2012.

식후 고혈당과 심혈관질환

윤지성

Postprandial Hyperglycemia and Cardiovascular Disease.

Ji Sung Yoon

Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. jsyoon9@ynu.ac.kr

Abstract

It is well established that diabetes mellitus is a major risk factor for cardiovascular disease (CVD), and tight glycemic control decreases CVD. Most physicians continue to depend on HbA1c and fasting plasma glucose levels as indicators for glycemic control. Increasing evidence suggests that increased postprandial glucose excursion is a strong contributing factor to the development of atherosclerosis and an independent risk factor for CVD in patients with or without diabetes. Glycemic excursions could exert their effects through oxidative stress, endothelial dysfunction, or formation of advanced glycation end-products. Several controlled interventional clinical trials have shown that treating postprandial hyperglycemia may have a beneficial effect on the endothelium and may reduce cardiovascular events. It is recommended that postprandial hyperglycemia be considered an important cardiovascular risk factor corresponding to other well known CV risk factors and should be monitored and managed properly.

Key Words: Hyperglycemia, Cardiovascular disease, Diabetes mellitus, Glucose tolerance